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| Effect of tangzhiqing on glycolipid metabolism in rats with experimental type 2 diabetes |
| Hits 2710 Download times 2295 Received:March 01, 2010 |
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| DOI
10.11656/j.issn.1673-9043.2010.02.09 |
| Key Words
type 2 diabetes mellitus;Tangzhiqing;glucose metabolism;lipid metabolism |
| Author Name | Affiliation | | LI Yu-hong | | | ZHANG De-qin | | | Wang Xi | | | 李俊青 | | | 张潇 | | | 曾森 | | | 刘虹 |
The TCM Research Institute in Tianjin University of TCM, Tianjin Key Laboratory of Chinese Medical Pharmacology, Key Laboratory of Science of TCM Formula by Ministry of Education, Tianjin China 300193
| | 胡利民 |
The TCM Research Institute in Tianjin University of TCM, Tianjin Key Laboratory of Chinese Medical Pharmacology, Key Laboratory of Science of TCM Formula by Ministry of Education, Tianjin China 300193
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| Abstract
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| [Objective] To observe the effects of Tangzhiqing (TZQ) on glycolipid metabolism in experimental type 2 diabetic rats.[Methods] Wistar rats were fed with high fat diet for 8weeks and then were injected intraperitoneally with streptozotocin (STZ,30 mg/kg) to induce experimental type 2 diabetes.The model rats were administrated with medicine at the dose of 6,3,1.5g of crude drug/kg for 30 days, using metformin hydrochloride tablets (0.25 g/kg),Xuezhikang (0.25 g/kg) as the control.At the end,the fasting blood glucose,serum lipid,insulin,glycosylated hemoglobin were measured.[Results] Compared with the model group,TZQ could obviously decrease the levels of the fasting blood glucose,serum lipid,insulin,glycosylated hemoglobin (P<0.05,P<0.01),and increase insulin-sensitivity index.[Conclusion] TZQ can effectively regulate glycolipid metabolism disorder. |
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