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| Association analysis of diseases，traditional Chinese medicine syndromes and herbal prescriptions for menstrual disorders related to diminished ovarian reserve |
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| DOI
10.11656/j.issn.1673-9043.2026.07.13 |
| Key Words
diminished ovarian reserve;menstrual disorders;complex network;medication pattern;association analysis |
| Author Name | Affiliation | E-mail | | DONG Wenbo | Department of Acupuncture, Beijing Hospital of Integrated Chinese and Western Medicine, Beijing 100039, China | | | ZHANG Lianghua | Department of Acupuncture, Beijing Hospital of Integrated Chinese and Western Medicine, Beijing 100039, China | | | LIU Congcong | Department of Acupuncture, Beijing Hospital of Integrated Chinese and Western Medicine, Beijing 100039, China | | | LI Wei | Department of Acupuncture, Beijing Hospital of Integrated Chinese and Western Medicine, Beijing 100039, China | et.998@163.com |
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| Abstract
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| [Objective] To investigate the associations among disease names，traditional Chinese medicine（TCM） syndromes，and herbal prescriptions in menstrual disorders related to ovarian functional decline based on entries from Zhonghua Yidian，and to provide literature-level evidence for clinical pattern differentiation and treatment planning. [Methods] Entries concerning scanty menstruation，delayed menstruation，and amenorrhea were retrieved and screened according to predefined inclusion and exclusion criteria，followed by terminology standardization and completeness verification. A total of 261 entries were included. Descriptive statistics were used to summarize the distributions of syndrome types and syndrome elements. Herbal co-occurrence network analysis and Phi coefficient analysis were performed to explore herb-syndrome associations and prescription patterns. [Results] Among the 261 entries，63（24.1%）were classified as scanty menstruation，74（28.4%）as delayed menstruation，and 124（47.5%） as amenorrhea（including early cessation of menses）. Marked differences in syndrome-type structures were observed across disease-name groups：the scanty menstruation group was dominated by qi-blood deficiency and spleen-kidney yang deficiency（73.0% combined）；the delayed menstruation group mainly presented kidney deficiency with liver constraint and qi stagnation（72.9% combined）；and the amenorrhea group was characterized by kidney deficiency with blood stasis and liver-kidney yin deficiency（71.8% combined）. Syndrome-element distributions also differed： the scanty menstruation group was deficiency-predominant，the delayed menstruation group featured prominent qi stagnation，and the amenorrhea group commonly involved yin deficiency，blood stasis，and essence depletion. In the herbal co-occurrence network，Danggui，Shudihuang，Baishao，and Chuanxiong occupied central positions， indicating a concentrated core prescription framework，while syndrome-associated herbs showed differentiation across syndrome types. [Conclusion] Co-occurrence and association analyses based on Zhonghua Yidian entries suggest that menstrual disorders related to ovarian functional decline differ across disease-name groups in their syndrome-type/element compositions and herb combinations. These findings may inform clinical pattern differentiation and prescription strategies；however，they reflect literature-level co-occurrence/association patterns rather than causal effects and should be interpreted cautiously. |
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