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| Research advances in traditional Chinese medicine for colorectal cancer treatment via the p53 signaling pathway |
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| DOI
10.11656/j.issn.1673-9043.2026.07.14 |
| Key Words
traditional Chinese medicine;p53 signaling pathway;colorectal cancer;research advance |
| Author Name | Affiliation | E-mail | | ZHU Yingkun | The Second Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450018, China | | | ZHANG Longjiang | The Second Department of Proctology, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou 450003, China | 19733033235@163.com | | NIU Mingliao | The Second Department of Proctology, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou 450003, China | | | LU Fei | The Second Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450018, China | | | QIAO Shuaibo | The Second Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450018, China | |
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| Abstract
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| The incidence and mortality of colorectal cancer are increasing annually，and its overall prognosis remains poor，posing a serious threat to human health. Although conventional treatments such as surgery， radiotherapy，and chemotherapy can control disease progression to some extent，they are limited by high recurrence and metastasis rates，adverse effects，and drug resistance，resulting in unsatisfactory therapeutic outcomes. Therefore，the development of safer and more effective therapeutic strategies is urgently needed. The p53 signaling pathway plays a pivotal role in regulating proliferation，differentiation，apoptosis，and autophagy of CRC cells and is considered a crucial target for anticancer therapy. Traditional Chinese medicine，with its multi-target，multi-level， and multi-pathway synergistic mechanisms，exhibits unique advantages in CRC prevention and treatment，including reducing recurrence and metastasis risk，alleviating chemoradiotherapy-induced toxicity，and improving patients’ quality of life. Studies have demonstrated that bioactive components such as alkaloids，flavonoids，saponins， polyphenols，and terpenoids，as well as herbal formulations including Jianpi Huayu Decoction，Bushen Jiedu Sanjie Formula，and Compound Zhejiang Fritillaria Granules，can exert anti-CRC effects by modulating p53 and its associated signaling pathways. The underlying mechanisms involve inducing apoptosis and autophagy，arresting the cell cycle，remodeling the tumor immune microenvironment，and reversing drug resistance. The review systematically summarizes recent advances in traditional Chinese medicine-mediated regulation of the p53 signaling pathway in CRC，aiming to provide insights and references for the development of novel anticancer agents and clinical applications. |
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