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Research progress of salidroside in the prevention and treatment of bone diseases

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DOI 10.11656/j.issn.1673-9043.2026.07.16

Key Words Rhodiola crenulata;salidroside;pharmacological mechanism;bone disease

Author Name Affiliation E-mail
XU Guangjing Military Medicine Section, Logistics University of Chinese People's Armed Police Force, Tianjin 300309, China
School of Chinese Materia Medica Pharmaceutical Engineering, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
JI Yansu Department of Pharmacy, Characteristic Medical Center of People's Armed Police Force, Tianjin 300162, China
ZHAO Yanmin Military Medicine Section, Logistics University of Chinese People's Armed Police Force, Tianjin 300309, China
QU Yanfei Military Medicine Section, Logistics University of Chinese People's Armed Police Force, Tianjin 300309, China
JIN Xin Military Medicine Section, Logistics University of Chinese People's Armed Police Force, Tianjin 300309, China jinxin1227@126.com
LIU Rui School of Chinese Materia Medica Pharmaceutical Engineering, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China liurui@tjutcm.edu.cn

Abstract

Salidroside is the main active component of Rhodiola crenulata，a plant from the Crassulaceae family. Recent studies have shown that salidroside exerts significant therapeutic potential for various bone diseases through multiple pharmacological mechanisms，including promoting bone formation，inhibiting bone resorption，and improving the bone microenvironment. It has demonstrated unique advantages in the prevention and treatment of osteoporosis，osteoarthritis，osteonecrosis，and bone tumors，highlighting the important value of salidroside in the treatment of bone diseases. The article reviews the research progress and pharmacological mechanisms of salidroside in the treatment of bone diseases，aiming to provide a theoretical basis and new therapeutic ideas for the treatment of bone diseases with traditional Chinese medicine.

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