| 摘要: |
| [目的] 探讨舒脉宁注射液(SHUMN)对脑缺血再灌注损伤的保护作用。[方法] 采用大鼠全脑缺血再灌注损伤模型,观察脑缺血前后血浆一氧化氮(NO)、内皮素(ET)和脑组织钙及含水量的变化。[结果] 脑缺血再灌注期血浆NO、ET和脑组织钙及含水量显著升高(P<0.05),使用舒脉宁注射液后,血浆NO、ET和脑组织钙及含水量明显降低。[结论] 舒脉宁注射液对脑缺血再灌注损伤确有保护作用。 |
| 关键词: 舒脉宁注射液 脑缺血再灌注损伤 一氧化氮 内皮素 |
| DOI：10.11656/j.issn.1672-1519.2012.01.24 |
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| 基金项目: |
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| Protective effect of SHUMAINING injection against ischemia-reperfusion injury of brain in rats |
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WANG Tong-ju, YANG Hong-ya, CHEN Wei-liang, TIAN Song-chao, GUO Bin-rong
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No.371 Central Hospital of the Chinese People's Liberation Army, Xinxiang 453000, China
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| Abstract: |
| [Objective] To investigate the protective effect of SHUMAINING injection against cerebral ischemia-reperfusion injury. [Methods] The cerebral ischemia-reperfusion injury was induced in rats. Then the blood NO, ET and brain Ca2+, brain water content of rats were respectively observed. [Results] In the stage of cerebral ischemia-reperfusion injury, all the blood NO, ET and brain Ca2+ and brain water content of rats increased significantly. After treating with SHUMAINING injection, all these parameters decreased significantly when compared with that before. [Conclusion] The protective effect of SHUMAINING injection in rats with cerebral ischemia-reperfusion injury is definite. |
| Key words: SHUMAINING injection cerebral ischemia-reperfusion injury nitric oxide endothelin-1 |
