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| 中药治疗慢性阻塞性肺疾病机制的研究进展 |
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贾蓓1,2, 何家琛1,2, 李佳玮1,2, 刘志东1,2
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1.天津中医药大学, 现代中药发现与制剂技术教育部工程中心, 天津 301617;2.天津中医药大学, 组分中药国家重点实验室, 天津 301617
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| 摘要: |
| 慢性阻塞性肺疾病（COPD）是一种常见的以持续气流受限为临床特征的疾病，表现为慢性支气管炎、肺实质病变、肺气肿、大气道炎症和重塑等病理特征，其患病率高、致残率高、病死率高，是全球死亡主要原因之一。治疗COPD常采用药物治疗的方式，如糖皮质激素类或支气管扩张剂等，其易出现耐药性，不良反应（皮疹、心动过速、头晕、代谢紊乱、精神障碍等）较多。中药可改善COPD患者肺功能与临床症状，减少COPD疾病的加重或复发，在治疗COPD方面具有一定前景。文章通过阐述COPD的发病机制、中药治疗COPD药理作用与治疗机制为研究，对进一步探索中药资源成为活性明确、安全性好的COPD治疗药物具有重要意义。 |
| 关键词: 慢性阻塞性肺疾病 发病机制 中药 |
| DOI：10.11656/j.issn.1672-1519.2023.09.19 |
| 分类号:R563 |
| 基金项目:中央引导地方科技发展专项（21ZYJDJC00020）；现代中医药海河实验室科技项目（22HHZYSS00005）；国家中医药管理局青年岐黄学者项目。 |
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| Research progress on the mechanism of traditional Chinese medicine in the treatment of chronic obstructive pulmonary disease |
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JIA Bei1,2, HE Jiachen1,2, LI Jiawei1,2, LIU Zhidong1,2
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1.Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique of Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2.State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
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| Abstract: |
| Chronic obstructive pulmonary disease（COPD） is a common disease with persistent airflow limitation as a clinical feature，manifested by chronic bronchitis，parenchymal lung lesions，emphysema，inflammation，airway remodeling，and other pathological features. Among its high prevalence，disability，and mortality rates，it is one of the leading causes of death worldwide. Medication is often used to treat COPD，such as glucocorticoids or bronchodilators，which are prone to drug resistance and have more adverse effects（rash，tachycardia，dizziness，metabolic disorders，mental disorders，etc.）. Traditional Chinese medicine improves lung function with clinical symptoms in COPD patients and reduces exacerbation or recurrence of COPD disease. There is promising research on its use in the treatment of COPD. This paper investigates the pathogenesis of slow obstructive pulmonary disease and the mechanism of Chinese herbal medicine for the treatment of slow obstructive pulmonary disease. It is significant for the further exploration of the activity and safety of Chinese herbal resources as therapeutic drugs for chronic obstructive pulmonary disease. |
| Key words: chronic obstructive pulmonary disease pathogenesis traditional Chinese medicine |
