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| 生物芯片在中药研究中的应用 |
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贾晓蕊1, 王丹妮1, 于卉娟1,2, 颜晓晖1,2, 王跃飞1,2, 柴欣1,2
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1.天津中医药大学中医药研究院, 现代中药创制全国重点实验室, 组分中药国家重点实验室, 天津 301617;2.现代中医药海河实验室, 天津 301617
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| 摘要: |
| 生物芯片是一种可以对生物样品进行高通量快速分析的微型化、集成化平台。作为一种新型的生物技术工具，生物芯片克服了传统生物学技术操作繁杂、自动化程度低、检测效率低等局限性，近年来在生物学、基础医学、中药学等研究领域发挥了重要作用。文章通过查阅国内外最新相关文献，分别对生物芯片在中药活性评价、作用机制解析、毒性成分筛选、质量评价等方面的应用进展进行综述，以期为生物芯片在中药领域的研究与推广应用提供新思路。 |
| 关键词: 生物芯片 中药 活性评价 作用机制 毒性成分 质量评价 |
| DOI：10.11656/j.issn.1672-1519.2025.05.18 |
| 分类号:R28 |
| 基金项目:国家自然科学基金青年项目（82204769）；国家重点研发计划（2021YFC1712905）；现代中医药海河实验室科技项目（22HHZYSS00007）。 |
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| Application of biochips in research on traditional Chinese medicine |
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JIA Xiaorui1, WANG Danni1, YU Huijuan1,2, YAN Xiaohui1,2, WANG Yuefei1,2, CHAI Xin1,2
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1.Institute of Traditional Chinese Medicine, State Key Laboratory of Chinese Medicine Modernization, State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2.Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China
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| Abstract: |
| Biochip is a miniaturized and integrated platform that can perform high-throughput and rapid analysis of biological samples. As a new biotechnology tool，biochip overcomes the limitations of traditional biological technology such as complicated operation，low automation，low detection efficiency，etc.，and has played an important role in biology，basic medicine，traditional Chinese medicine and other research fields in recent years. By reviewing the latest relevant literature at home and abroad，the article reviews the progress of biochip application in the evaluation of activity，mechanism of action，toxicity screening，and quality assessment of traditional Chinese medicine，with a view to providing new ideas for the research and popularization of the application of biochip in the field of traditional Chinese medicine. |
| Key words: biochip traditional Chinese medicine activity evaluation mechanism of action toxic components quality evaluation |
