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| 针灸干预化疗所致免疫抑制机制的研究进展 |
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刘婷1,2, 张诗雯1,2, 王也1,2, 董佳文1,2, 唐慧1,2, 李晶1,2
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1.天津中医药大学第一附属医院, 天津 300193;2.中医国家临床医学研究中心, 天津 300193
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| 摘要: |
| 化疗作为恶性肿瘤的一线治疗手段，在发挥抗肿瘤作用的同时，会引发显著免疫抑制，破坏宿主免疫稳态，并通过神经内分泌系统紊乱，导致机体抗感染及抗肿瘤能力双重受损，进而影响治疗实施与患者生存质量。近年研究证实，针灸在改善化疗后免疫抑制中具有独特价值，尽管目前已有大量基础和临床研究，但针灸改善化疗免疫抑制的精准分子机制尚待明确。文章系统综述发现，针灸可通过调控免疫细胞亚群平衡、重塑细胞因子平衡、调节信号通路活性及协同改善肠道免疫紊乱等，有效逆转化疗后的免疫抑制状态。这为阐释针灸免疫调控的生物学机制提供了理论支撑，也为优化肿瘤综合治疗方案提供了新路径。 |
| 关键词: 针灸 恶性肿瘤 化疗 免疫抑制 不良反应 |
| DOI：10.11656/j.issn.1672-1519.2026.02.16 |
| 分类号:R246.5 |
| 基金项目:国家自然科学基金面上项目（81674056）；国家中医针灸临床医学研究中心针灸研究所内部课题（ZJJBGS2024004）；国家中医针灸临床医学研究中心开放课题（NCRCOP2024010）；天津中医药大学第一附属医院自主立项科研课题（JYTC2025030） |
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| Research progress on the mechanism of chemotherapy-induced immunosuppression by acupuncture intervention |
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LIU Ting1,2, ZHANG Shiwen1,2, WANG Ye1,2, DONG Jiawen1,2, TANG Hui1,2, LI Jing1,2
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1.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.National Clinical Research Center for Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| As a first-line treatment for malignant tumors, chemotherapy, while exerting anti-tumor effects, can induce significant immune suppression, disrupt host immune homeostasis, and cause disorders of the neuroendocrine system. This leads to dual impairment of the body's anti-infective and anti-tumor capabilities, thereby affecting the implementation of treatment and the quality of life of patients. Recent studies have confirmed that acupuncture has unique value in improving immune suppression after chemotherapy. Although there have been a large number of basic and clinical studies, the precise molecular mechanisms by which acupuncture ameliorates chemotherapy-induced immune suppression remain to be clarified. This systematic review found that acupuncture can effectively reverse the immune suppression state after chemotherapy by regulating the balance of immune cell subsets, reshaping cytokine balance, modulating the activity of signaling pathways, and synergistically improving intestinal immune disorders. This provides theoretical support for explaining the biological mechanisms of acupuncture's immune regulation and offers a new approach for optimizing comprehensive tumor treatment regimens. |
| Key words: acupuncture malignancy chemotherapy immunosuppression adverse effects |
