| 摘要: |
| [目的] 探讨复方苁蓉益智胶囊联合十二井穴放血疗法对急性脑梗死后血管性痴呆（VaD）患者认知功能、氧化应激及血液流变学的影响。[方法] 选取2021年11月—2023年6月收治的120例急性脑梗死后VaD患者，采用随机数字表法分为两组，其中对照组60例采用盐酸多奈哌齐片治疗，治疗组60例采用复方苁蓉益智胶囊和十二井穴放血疗法治疗。评估患者治疗前后的中医证候积分、简易精神状态检查量表（MMSE）评分、日常生活能力量表（ADL）评分、氧化应激指标、血液流变学指标以及临床疗效。[结果] 治疗后，两组患者MMSE评分、ADL评分以及血清超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）水平均升高，大脑中动脉（MCA）、基底动脉、大脑前动脉（ACA）的平均血流速度加快（P<0.05），且治疗组升高幅度优于对照组（P<0.05）；而两组中医证候积分以及血清丙二醛（MDA）水平显著降低（P<0.05），且治疗组指标低于对照组（P<0.05）。治疗组与对照组临床疗效比对[95.00%（57/60）vs.80.00%（48/60）]，差异有统计学意义（P<0.05）。[结论] 采用复方苁蓉益智胶囊联合十二井穴放血疗法治疗急性脑梗死后VaD患者，可改善其认知功能，调节氧化应激状态，并优化血液流变学。 |
| 关键词: 复方苁蓉益智胶囊 十二井穴 放血疗法 急性脑梗死 血管性痴呆 |
| DOI：10.11656/j.issn.1672-1519.2026.07.05 |
| 分类号:R743.3 |
| 基金项目:河北省中医药管理局科研计划项目（2022170）。 |
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| Observation on clinical effects of combination of Compound Congrong Yizhi Capsule and bloodletting at the twelve Jing-well points on cognitive function，oxidative stress，and hemorheology in patients with vascular dementia after acute cerebral infarction |
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SHI Hui1, XING Xin1, SUN Shuxian2, HUANG Suling2, ZHANG Tao3
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1.Department of Brain Diseases, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang 050000, China;2.Department of Laboratory Medicine, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang 050000, China;3.Department of General Affairs, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang 050000, China
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| Abstract: |
| [Objective] To explore the effects of combination of Compound Congrong Yizhi Capsules and bloodletting at the twelve Jing-well points on cognitive function，oxidative stress，and hemorheology in patients with vascular dementia（VaD）after acute cerebral infarction. [Methods] From November 2021 to June 2023，120 patients with VaD after acute cerebral infarction admitted to our hospital were included and randomly divided into two groups via random number table method. The control group（60 cases）were treated with donepezil hydrochloride tablets，while the therapy group（60 cases）were treated with the union of compound Congrong Yizhi capsules and bloodletting at the twelve Jing-well points. The traditional Chinese medicine syndrome scores，Mini Mental State Examination（MMSE）score，Activities of Daily Living（ADL）score，oxidative stress indicators，hemorheological indicators，and clinical efficacy before and after therapy were evaluated. [Results] After therapy，the MMSE score，ADL score，and serum superoxide dismutase （SOD）and glutathione peroxidase（GSH-Px）increased in both groups，the average blood flow velocities of the middle cerebral artery （MCA），basilar artery，and anterior cerebral artery（ACA）increased（P<0.05），and the therapy group had better changes than the control group（P<0.05）. The TCM syndrome scores，and serum malondialdehyde（MDA）reduced prominently in both groups（P<0.05）， and the therapy group had lower indicators than the control group（P<0.05）. The comparison of clinical efficacy between the therapy group and the control group [95.00%（57/60）vs. 80.00%（48/60）] showed a significant difference（P<0.05）. [Conclusion] The combination of Compound Congrong Yizhi Capsules and bloodletting at the twelve Jing-well points can improve cognitive function， regulate oxidative stress status，and optimize hemorheology in patients with VaD after acute cerebral infarction. |
| Key words: Compound Congrong Yizhi Capsule twelve Jing-well points bloodletting therapy acute cerebral infarction vascular dementia |
