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| Stability Investigation of Salvianolic Acid B in the Minosis Fluid of Digestive Tract |
| Hits 2250 Download times 2245 Received:January 02, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2006.04.33 |
| Key Words
salvianolic acid B;mimosis body fluid;stability |
| Author Name | Affiliation | | CHAI Shi-wei | Tianjin University of TCM, Tianjin 300193, China | | PAN Gui-xiang | Tianjin University of TCM, Tianjin 300193, China | | ZHANG Yan-bin | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To investigate the stability of salvianolic acid B in minosis body pH environment in vitro.[Methods] Minosis pH value of body fluid was carried out by using NaHCO3 and HCL.The content change of salvianolic acid B was determined by HPLC.The mobile phase was acetonitrile-1% acetic acid(23:77)and detection wavelength was 281 nm.[Results] The content of salvianolic acid B decreased 1.5% at half an hour and 11.2% at four hours in gastric juice of empted stomach.But there wasn’t any change at zero to sixth hour in gastric juice of food-filled stomach.The content of salvianolic acid B decreased 3.9% at three hours and 6.7% at six hours in small intestinal juice.But it was instable in large intestinal juice.[Conclusions] The method was sensitive,accurate and may be used to carry out qualitative identification and quality control of salvianolic acid B. |
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