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| Effect of Xi Feng capsule on expression of MRP1 of hippocampus and cortex in epileptic rats induced by lithium-pilocarpine |
| Hits 2512 Download times 1954 Received:January 20, 2012 |
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| DOI
10.11656/j.issn.1672-1519.2012.02.19 |
| Key Words
intractable epilepsy;Xi Feng capsule;pilocarpine;MRP1 |
| Author Name | Affiliation | | LI Xin-min | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | REN Yan-yan | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | CHEN Hui | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | LU Yan-li | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective]To study the intervention effect of Xi Feng capsule on medicine-related protein 1(MRP1)of hippocampus and cortex in epileptic rats induced by Lithium-Pilocarpine.[Methods]1)Epilepsy was duplicated in rats with lithium-pilocarpine chemical ignition.2)All the experimental rats were randomly divided into eight groups:normal control group,model group,Xi Feng interventiongroup(Xi Feng high-dose group),Xi Feng intervention group(Xi Feng middle-dose group),Xi Feng intervention group(Xi Feng low-dose group(Xi Feng high-dose group),Xi Feng intervention group(Xi Feng middle-dose group),Xi Feng intervention group(Xi Feng low-dose group),Xi Feng high-dose+CBZ group,Xi Feng high-dose+CBZ 1/2 dose group,CBZ group.3)The expression of MRP1 of hippocampu and cortex in epileptic rats was observed by Western-blot.[Results]The result of Western-blot method suggested that there was a significant difference between intervention group of Xi Feng capsule and model group(P<0.05).[Conclusion]Xi Feng capsule single and combined with CBZ could efficiently depress the overexpression of MRP1 of the hippocampus and cortex in epileptic rats induced by Lithium-Pilocarpine. |
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