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| Research progress of platelet ADP receptor and its antagonist |
| Hits 2628 Download times 3150 Received:December 31, 2016 |
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| DOI
10.11656/j.issn.1672-1519.2017.04.19 |
| Key Words
platelet;P2Y1 receptor;P2Y12 receptor;P2X1 receptors;antagonists |
| Author Name | Affiliation | E-mail | | ZHAI Ting | Tianjin State Key Laboratory of Modern Chinese Medicine-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China | | | HUA Sheng-yu | Tianjin State Key Laboratory of Modern Chinese Medicine-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | bravo2008@163.com |
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| Abstract
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| Adenosine diphosphate (ADP) is the first known low molecular weak platelet aggregation inducer. It is stored in platelet dense granules with high concentration. When the platelets were stimulated, ADP was released from the dense particles . As a secondary agonist, it can strengthen induction on itself and other revulsants. ADP contributes to stabilize thrombus by acting on a variety of receptors. Antagonists of ADP receptor can inhibit the expression and activation of ADP receptor, and can also inhibit platelet aggregation effectively. The antagonist plays an important role in treating thrombotic diseases. Currently, as ADP receptor antagonists have good antithrombotic activity and higher safety, it has been widely used in clinic. The data of different types of ADP receptor and some important receptor antagonists were reviewed in this study. We intent to provide a certain guide in the development of ADP receptor antagonists. |
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