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| Effects of fistular onion stalk extract on the expression of ATPase6 and ATPase8 on non-alcoholic fatly liver disease model rats |
| Hits 2003 Download times 1299 Received:August 20, 2018 |
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| DOI
10.11656/j.issn.1672-1519.2018.12.18 |
| Key Words
fistular onion stalk extract;non-alcoholic fatty liver disease;ATPase6;ATPase8 |
| Author Name | Affiliation | E-mail | | ZHENG Ding | Hubei university of Traditional Chinese Medicine, Wuhan 430065, China | | | SHI Zhaohong | Wuhan Chinese and Western Medicine Hospital, Wuhan 430022, Chian | zhaohshi@126.com | | GUO Jie | Wuhan Chinese and Western Medicine Hospital, Wuhan 430022, Chian | | | ZHANG Shu | Wuhan Chinese and Western Medicine Hospital, Wuhan 430022, Chian | | | FU Lihe | Hubei university of Traditional Chinese Medicine, Wuhan 430065, China | | | LIU Fan | Hubei university of Traditional Chinese Medicine, Wuhan 430065, China | | | TU Beilei | Hubei university of Traditional Chinese Medicine, Wuhan 430065, China | |
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| Abstract
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| [Objective] To observing the expression of ATPase6 and ATPase8 and explore the probable mechanism of fistular onion stalk extract in treating nonalcoholic fatty liver disease model in rats.[Methods] The 50 male SD rats were randomly divided into normal group, model group, low-dose fistular onion stalk group, medium dose fistular onion stalk group, high-dose fistular onion stalk group, and 10 in each group. The rats were fed with a high-fat diet to replicate the NAFLD model. After 10 weeks of modeling, the extract of the onion was given for 4 weeks. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and triglyceride (TC) and cholesterol (TG) were measured. The changes of liver tissue structure wereexpression of ATPase6 and ATPase8 mRNA in liver tissues of rats.[Results] Compared with the normal group, the model group showed obvious hepatic steatosis. The level of serum ALT, AST, TC and TG were higher than normal group(P<0.05). The expression of ATPase6 and ATPase8 mRNA was significantly decreased(P<0.05). Compared with the model group, the lipid degeneration in the liver was alleviated, the level of serum ALT, AST, TC and TG were all decreased, the expression of ATPase6 and ATPase8 mRNA were significantly increased in low-dose fistular onion stalk group, medium dose fistular onion stalk group and high-dose fistular onion stalk group(P<0.05).[Conclusion] Fistular onion stalk extract can improve hepatic steatosis, which may be associated with improved expression of ATPase6 and ATPase8, and increased mitochondrial ATP synthesis. |
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