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| Research progress on the dose-response relationship of acupuncture in the treatment of knee osteoarthritis |
| Hits 124 Download times 25 Received:January 20, 2026 |
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| DOI
10.11656/j.issn.1672-1519.2026.06.18 |
| Key Words
knee osteoarthritis;manipulation techniques;time parameters;dose-effect relationship |
| Author Name | Affiliation | E-mail | | LI Xiang | Experimental Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Jiaqi | Experimental Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Hongxia | Experimental Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
College of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | HUANG Jing | Experimental Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Ruoyu | Experimental Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YUAN Ruoyu | Experimental Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | XU Zhifang | Experimental Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
National Clinical Research Center for Chinese Medicine, Tianjin 300193, China
Tianjin Key Laboratory of Modern Chinese Medicine Theory Innovation and Transformation, Tianjin 301617, China
College of Acupuncture and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | xuzhifangmsn@hotmail.com |
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| Abstract
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| Acupuncture has demonstrated significant efficacy in the treatment of knee osteoarthritis（KOA）. Studies on different acupuncture therapies for KOA have revealed that combined manipulations or integrated treatments are predominantly used in clinical practice. Appropriately prolonging acupuncture duration and increasing treatment frequency can enhance clinical outcomes. However， the lack of uniform stimulation parameters has resulted in the absence of scientifically rigorous quantification and standardization of parameters for acupuncture in KOA treatment，making it difficult to replicate its efficacy and thereby limiting the widespread application of acupuncture therapy. This study investigates the intervention methods，time parameters，and the relationship between syndrome types and dose-effect in acupuncture treatment of KOA. It systematically analyzes the dose-effect relationship between acupuncture stimulation dosage and clinical efficacy，aiming to provide evidence-based support for the establishment of a standardized treatment system and facilitate the standardization and popularization of clinical acupuncture in KOA management. |
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