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| Research progress on the treatment of central nervous system diseases by acupuncture regulation of ferroptosis |
| Hits 127 Download times 28 Received:January 30, 2026 |
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| DOI
10.11656/j.issn.1672-1519.2026.06.19 |
| Key Words
ferroptosis;central nervous system diseases;acupuncture;review |
| Author Name | Affiliation | E-mail | | WANG Huile | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHOU Zhiyu | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | zzyxszy@163.com | | YU Yajun | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Guan | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | ZHU Zheng | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | LI Xinju | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | QIN Siru | School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Jiabao | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | |
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| Abstract
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| Acupuncture therapy has a long history of application in the treatment of central nervous system（CNS）diseases with remarkable efficacy. Its mechanism of action has been the subject of in-depth exploration by subsequent researchers. Ferroptosis is a new form of programmed cell death. Compared with other known programmed cell death，ferroptosis is characterized by distinct features in cell morphology，biochemistry and genetics. The core mechanism involves iron metabolism disorders，lipid peroxidation，and dysfunction of antioxidant defense. Ferroptosis is closely related to the occurrence and progression of various CNS diseases，but its mechanism of action remains to be clarified. In-depth analysis of the effect of acupuncture therapy on ferroptosis process and its connection with CNS diseases will provide a new theoretical basis for the innovative application of acupuncture therapy in the treatment of CNS diseases. By systematically reviewing and integrating the relevant literature，this article aims to advance the current understanding of the scientific mechanisms underlying acupuncture in the treatment of CNS diseases. |
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