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| Research progress on the mechanism and clinical application of Drynariae Rhizoma and its active components in promoting fracture healing |
| Hits 219 Download times 75 Received:January 20, 2026 |
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| DOI
10.11656/j.issn.1672-1519.2026.06.20 |
| Key Words
Drynaria Rhizoma;fracture healing;flavonoids;osteoblasts;osteoporosis |
| Author Name | Affiliation | E-mail | | ZHANG Xi | Tianjin Hospital, Tianjin University, Tianjin 300211, China | | | ZHU Chunxia | Tianjin Hospital, Tianjin University, Tianjin 300211, China | | | SUN Jie | Tianjin Hospital, Tianjin University, Tianjin 300211, China | | | REN Zhipeng | Tianjin Hospital, Tianjin University, Tianjin 300211, China | | | YUAN Yu | Tianjin Hospital, Tianjin University, Tianjin 300211, China | tjyycsk@163.com |
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| Abstract
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| Drynaria Rhizoma is a traditional and commonly used Chinese herbal medicine renowned for its efficacy in promoting fracture healing and tonifying kidney to strengthen bones. Studies indicate that its primary bioactive constituents，flavonoids（with naringin as the representative compound），facilitate bone healing through multiple mechanisms，including：increasing bone mineral density，enhancing osteoblast differentiation and mineralization，regulating signaling pathways such as BMP- 2，inhibiting osteoclast activity，and promoting angiogenesis. Clinical practice and preliminary research demonstrate that Drynaria Rhizoma，used alone or in combination，can improve bone density and accelerate healing in patients with osteoporotic fractures，exhibiting a favorable safety profile. Current investigations predominantly focus on flavonoid components；future studies should explore the roles of other chemical constituents and conduct more rigorous clinical trials to establish optimal therapeutic protocols. |
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