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| Chinese patent medicine Weifuchun combined with Western medicine for the intervention of gastric precancerous lesions: A systematic review and Meta-analysis |
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| DOI
10.11656/j.issn.1672-1519.2026.08.07 |
| Key Words
Weifuchun;gastric precancerous lesions;glandular atrophy;intestinal metaplasia;dysplasia;Meta-analysis;integrated traditional Chinese and Western medicine therapy |
| Author Name | Affiliation | E-mail | | CHENG Ningtao | School of Public Health, Zhejiang University School of Medicine, Hangzhou 310058, China | | | YANG Bowen | State Key Laboratory of Modern Chinese Medicine Innovation, Tianjin 301617, China | | | ZHANG Yizu | State Key Laboratory of Modern Chinese Medicine Innovation, Tianjin 301617, China | | | XIONG Ke | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Mingyan | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Jiabao | State Key Laboratory of Modern Chinese Medicine Innovation, Tianjin 301617, China | | | LI Huizhen | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300151, China | | | HUANG Ming | State Key Laboratory of Modern Chinese Medicine Innovation, Tianjin 301617, China | drhuang1027@foxmail |
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| Abstract
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| Objective Gastric precancerous lesions are a pivotal stage in the occurrence and progression of gastric cancer, characterized by progressive core pathological changes including glandular atrophy, intestinal metaplasia, and dysplasia. Routine Western medicine can only relieve clinical symptoms such as upper abdominal discomfort in patients and control local inflammation, but has limited efficacy in reversing the above core pathological changes, which falls short of the clinical needs for halting the carcinogenic process. Chinese patent medicine Weifuchun is a commonly used Chinese patent medicine for the prevention and treatment of gastric precancerous lesions; however, existing studies are mostly single-center, small-sample randomized controlled trials (RCTs), with insufficient evidence grade and lack of systematic evaluation. Methods This study strictly followed the Cochrane Handbook for Systematic Reviews of Interventions and the PRISMA 2020 statement to conduct a systematic review. Chinese and English databases were systematically searched up to March 2026 to include RCTs comparing Chinese patent medicine Weifuchun combined with routine Western medicine versus the same regimen of Western medicine alone in the treatment of gastric precancerous lesions. Literature screening, data extraction and risk of bias assessment were independently completed by two researchers. Meta-analysis was performed using R software version 4.3.3. Sensitivity analysis, subgroup analysis and publication bias test were conducted for the primary outcomes. For outcome indicators with publication bias, the trim-and-fill method was further applied for correction to verify the robustness of the results. Results A total of 13 RCTs involving 1 394 patients were included. The results of Meta-analysis showed that Chinese patent medicine Weifuchun combined with Western medicine was significantly superior to Western medicine alone in improving glandular atrophy (SMD=-1.78, 95%CI: -2.22 to-1.33, P < 0.001) and intestinal metaplasia (SMD=-2.05, 95%CI: -2.79 to -1.31, P < 0.001). Two studies suggested that it also exerted an improving effect on dysplasia. Subgroup analysis showed that a treatment course of ≥8 weeks had a more significant improvement effect on intestinal metaplasia. Publication bias test indicated that small sample effect existed in partial outcomes, and the results still maintained statistical significance after correction by the trim-and-fill method, which demonstrated that the conclusion of this study was robust and reliable. Conclusion Current evidence indicates that Chinese patent medicine Weifuchun combined with routine Western medicine can effectively intervene in gastric precancerous lesions. It can not only relieve clinical symptoms, but also reverse the core pathological changes of gastric precancerous lesions, which provides a safe and effective evidence-based basis for the integrated traditional Chinese and Western medicine prevention and treatment of this disease. However, affected by the limitations of the included studies (such as small sample size and mainly single-center studies), the conclusion of this study still needs to be further verified by more large-sample, multi-center, high-quality RCTs with longer follow-up duration. |
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