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| Preparation, characterization and gastrointestinal retention evaluation of a Bletilla striata polysaccharide gastric floating formulation loaded with Xuanfu Daizhe Tang |
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| DOI
10.11656/j.issn.1672-1519.2026.08.08 |
| Key Words
Xuanfu Daizhe Tang;Bletilla striata polysaccharide;gastroesophageal reflux disease;gastrointestinal retention;gastric floating agent |
| Author Name | Affiliation | E-mail | | LI Yifan | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | TAN Lihua | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Meng | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | wangmeng@tjutcm.edu.cn |
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| Abstract
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| Objective To prepare a Bletilla striata polysaccharide gastric floating agent loaded with Xuanfu Daizhe Tang extract (XDT@BSP-FS) for gastroesophageal reflux induced nausea and vomiting, and to evaluate its floating and gastric retention properties. Methods A Bletilla striata polysaccharide (BSP) -glyceryl monooleate (GMO) hydrogel framework (BSP-FS) was prepared via a mixed swelling method, followed by loading with Xuanfu Daizhe Tang to yield XDT@BSP-FS. The floating performance, microstructure, physicochemical properties, rheological and mechanical properties, in vitro digestion behavior, and in vivo retention behavior were systematically evaluated. Results XDT@BSP-FS exhibited immediate floating (0 s), formed a floating layer with a thickness of 0.52 cm, and maintained stable buoyancy for over 8 h. Structural characterization revealed the formation of a dense, lamellar porous network within XDT@BSP-FS. Thermal analysis (DSC) and Fourier transform infrared spectroscopy (FT-IR) indicated that Xuanfu Daizhe Tang existed within the BSP-FS framework predominantly through physical interactions. At equivalent doses, XDT@BSP-FS demonstrated superior mechanical toughness compared with the commercially available product Gaviscon®. In vivo and ex vivo fluorescence imaging demonstrated that, following intragastric administration of XDT@BSP-FS, the gastrointestinal fluorescence signal persisted for more than 4 h in vivo, and obvious fluorescence was still detectable at 6 h ex vivo. By contrast, the fluorescence signal in the indocyanine green (ICG) aqueous solution group was already markedly attenuated at 4 h. Conclusion XDT@BSP-FS exhibited rapid flotation, prolonged floating duration, and favorable in vivo retention behavior, providing a reference for the development of gastroretentive drug delivery systems for gastroesophageal reflux related diseases. |
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