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| Chinese herbal medicine intervention in ferroptosis: A novel therapeutic strategy for diabetic microvascular complications |
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| DOI
10.11656/j.issn.1672-1519.2026.08.16 |
| Key Words
Chinese herbal medicine;ferroptosis;diabetes mellitus;diabetic microvascular disease;diabetic retinopathy;diabetic kidney disease |
| Author Name | Affiliation | E-mail | | CHENG Siqi | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | | | ZHANG Lerong | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | | | LI Jiamu | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | | | XU Yunkai | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | | | JIANG Chen | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | jiangchen_doctor@163.com |
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| Abstract
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| Diabetic microvascular complications significantly impact patient prognosis, with various clinical manifestations potentially sharing a common pathological foundation. Ferroptosis, a non-apoptotic form of iron-dependent cell death, is posited as a potential unifying mechanism underlying these complications. This article provides a comprehensive overview of the role of ferroptosis in diabetic microvascular complications, elucidating its contribution to the onset and progression of diabetic retinopathy, nephropathy, neuropathy, cardiomyopathy, and foot ulcers through mechanisms such as intracellular iron overload, lipid peroxidation, and antioxidant defense imbalance. Furthermore, the article reviews the advancements in research on traditional Chinese medicines and their active components in inhibiting ferroptosis by modulating pathways such as regulating nuclear factor erythroid 2-related factor 2 (Nrf2), glutathione (GSH) /glutathione peroxidase 4 (GPX4), and iron metabolism, thereby ameliorating these complications. The article underscores the value of targeting ferroptosis with traditional Chinese medicines for preventing and treating diabetic microvascular issues. |
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