|
| Research progress on the mechanism of tetramethylpyrazine in regulating “vascular-osteogenic coupling” in osteoarthritis subchondral bone via miR-20b |
| Hits 115 Download times 85 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2026.08.17 |
| Key Words
osteoarthritis;subchondral bone;vascular-osteogenic coupling;tetramethylpyrazine;microRNA-20b |
| Author Name | Affiliation | E-mail | | DONG Jiahao | The First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming 650500, China | | | CHEN Tao | Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming 650021, China | henpao@126.com | | XIA Yifeng | The First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming 650500, China | | | YU Weijie | Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming 650021, China | | | PENG Zhongyu | Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming 650021, China | | | LONG Yuan | The First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming 650500, China | | | ZHAO Lingrui | The First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming 650500, China | |
|
| Abstract
|
| The imbalance of"vascular-osteogenic coupling"in the subchondral bone is a pivotal pathological link in the progression of osteoarthritis (OA), involving hyperactivity of angiogenesis mediated by the vascular endothelial growth factor (VEGF) signaling pathway and dysregulation of osteogenic differentiation governed by the bone morphogenetic protein 2 (BMP2) /Smad1 signaling axis. Grounded in the "holistic regulation" theory of traditional Chinese medicine (TCM), this study proposes, for the first time, an innovative hypothesis that tetramethylpyrazine (TMP, ligustrazine) may restore subchondral bone homeostasis by targeting microRNA miR-20b to synergistically regulate the aforementioned dual signaling pathways. A systematic review of the evidence indicates that miR-20b can inhibit the VEGF pathway and activate the BMP2/Smad1 pathway, while TMP exhibits multiple pharmacological activities, including suppressing angiogenesis, promoting osteogenesis, and modulating miRNA expression. This hypothesis provides a novel paradigm for elucidating the "multi-target" intervention strategy of Chinese herbal medicine in complex diseases and offers potential therapeutic targets and a candidate drug for disease-modifying OA therapy. Future research should employ gene-edited animal models, single-cell omics, and targeted delivery systems to further validate this mechanism, thereby fostering the integrated development of TCM modernization and precision medicine. |
|
|
|
|
|
|
|
