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| Research progress on the mechanism of mitophagy in chronic hepatitis B-associated liver fibrosis and the intervention of traditional Chinese medicine |
| Hits 2 Download times 0 Received:April 25, 2026 |
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| DOI
10.11656/j.issn.1672-1519.2026.09.15 |
| Key Words
mitophagy;chronic hepatitis B;liver fibrosis;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | MA Liang | Graduate School, Guangxi University of Chinese Medicine, Nanning 530001, China | | | WEN Bin | The Second Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530011, China | 286449737@qq.com | | DENG Xin | School of Basic Medicine, Guangxi University of Traditional Chinese Medicine, Nanning 530200, China | |
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| Abstract
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| Mitophagy specifically clears damaged mitochondria to maintain cellular homeostasis. Chronic hepatitis B（CHB）is a major cause of liver fibrosis，cirrhosis，and hepatocellular carcinoma. HBV hijacks mitophagy to promote replication and immune evasion；the resulting mitophagy dysfunction and persistent inflammation activate hepatic stellate cells（HSCs），ultimately causing liver fibrosis. Thus，elucidating the bidirectional regulatory mechanisms of mitophagy in CHB progression to liver fibrosis is crucial. Currently， Traditional Chinese Medicine（TCM）shows remarkable efficacy in inhibiting viral replication，alleviating inflammation，and blocking HSC activation by targeting mitophagy. This review outlines the pathological mechanisms of mitophagy in this process and corresponding TCM strategies，aiming to provide a theoretical basis for the precision treatment of CHB-related liver fibrosis and new perspectives for TCM modernization. |
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