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| Research progress of traditional Chinese medicine monomer and compound regulating lipophagy to improve hyperlipidemia |
| Hits 2 Download times 0 Received:July 14, 2026 |
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| DOI
10.11656/j.issn.1672-1519.2026.09.16 |
| Key Words
traditional Chinese medicine;lipophagy;hyperlipidemia;lipid metabolism |
| Author Name | Affiliation | E-mail | | LI Mengyao | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YU Chengyuan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHU Zhuanlin | Shandong Huayang Pharmaceutical Co., Ltd., Zibo 255185, China | | | ZHANG Yanjun | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China | | | YIN Qingsheng | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | carrysable@163.com | | ZHUANG Pengwei | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China | zhuangpengwei@163.com |
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| Abstract
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| Hyperlipidemia is a common metabolic disorder characterized by dysregulated lipid metabolism and serves as a significant risk factor for cardiovascular diseases. Lipophagy，a selective form of autophagy，plays a key role in regulating lipid homeostasis by degrading intracellular lipid droplets. Recent studies have shown that single compounds and compound formulations of traditional Chinese medicine（TCM）can ameliorate hyperlipidemia through coordinated regulation of lipophagy via multiple targets and pathways. This article systematically reviews the molecular mechanisms of lipophagy and its role in hyperlipidemia，with a focus on the involvement of core signaling pathways such as AMPK/mTOR，TFEB，and PI3K/Akt in the regulation of lipophagy. It also summarizes recent progress in research on TCM single compounds，including Astragaloside Ⅳ，Geniposide，Emodin，Hyperin，and Ginsenoside，as well as TCM compound formulations such as Zexie Decoction，Huayu Qutan Formula，Kundan Formula，and Wuling Powder in improving hyperlipidemia by modulating lipophagy. The aim is to provide new theoretical foundations and research directions for the prevention and treatment of hyperlipidemia and related metabolic diseases using TCM. |
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