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| Research progress in construction and application of traditional Chinese medicine polysaccharide-based oral nanodelivery systems |
| Hits 0 Download times 0 Received:June 27, 2026 |
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| DOI
10.11656/j.issn.1672-1519.2026.09.17 |
| Key Words
traditional Chinese medicine polysaccharides;oral administration;nanodelivery systems;bioavailability;targeting |
| Author Name | Affiliation | E-mail | | LI Jingbai | School of Chinese Meateria Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Modern Traditional Chinese Medicine Discovery and Formulation Technology Engineering Research Center of the Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | GAO Ruojie | School of Chinese Meateria Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Modern Traditional Chinese Medicine Discovery and Formulation Technology Engineering Research Center of the Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Ying | Modern Traditional Chinese Medicine Discovery and Formulation Technology Engineering Research Center of the Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | zhangying120@hotmail.com | | LIU Zhidong | School of Chinese Meateria Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Modern Traditional Chinese Medicine Discovery and Formulation Technology Engineering Research Center of the Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | lonerliuzd@163.com |
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| Abstract
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| Oral nanodelivery systems encounter significant barriers in the gastrointestinal tract，notably rapid clearance by the mucus layer，poor epithelial cellular uptake，and a lack of specific targeting capabilities. Traditional Chinese medicine polysaccharides （TCMPS），a class of crucial active components in herbal medicine，offer an ideal strategy to circumvent these limitations owing to their unique molecular architectures and inherent biological properties. This review comprehensively summarizes the drug-excipient integration strategy of TCMPS，highlighting their dual roles as both active therapeutics and functional excipients. We systematically elaborate on the key mechanisms by which TCMPS potentiate oral nanocarriers：mucoadhesion，receptor-mediated endocytosis， biological repair of the intestinal barrier，and synergistic immunomodulation coupled with lymphatic targeting. Furthermore，we highlight recent advances in the application of representative TCMPS，such as those derived from Cistanche deserticola，Astragalus membranaceus，and Lentinus edodes，in oral nanoformulations. Future research should prioritize the development of precise functional polysaccharide fragments，the elucidation of their structure- activity relationships，and the construction of multifunctional，intelligent delivery platforms to facilitate the clinical translation of TCMPS-based therapeutics. |
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