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| Preparation and evaluation of Yiqi Qingfei Granules placebo based on machine sensory technology |
| Hits 115 Download times 72 Received:August 05, 2026 |
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| DOI
10.11656/j.issn.1672-1519.2026.10.09 |
| Key Words
Yiqi Qingfei Granule;placebo;similarity evaluation;machine sensory technology |
| Author Name | Affiliation | E-mail | | TENG Tingting | National Key Laboratory of Modern Chinese Medicine Innovation and Manufacturing, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin Modern Innovation Chinese Medicine Technology Co., Ltd., Tianjin 300380, China | | | LIANG Lipeng | Tianjin Modern Innovation Chinese Medicine Technology Co., Ltd., Tianjin 300380, China | | | LUO Lifei | National Key Laboratory of Modern Chinese Medicine Innovation and Manufacturing, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin Modern Innovation Chinese Medicine Technology Co., Ltd., Tianjin 300380, China | | | DING Hui | Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China | | | SONG Hangyu | China Resources Sanjiu Medical & Pharmaceutical Co., Ltd., Shenzhen 518110, China | | | ZHANG Yanbin | China Resources Sanjiu Medical & Pharmaceutical Co., Ltd., Shenzhen 518110, China | zhangyanbin@999.com.cn | | SONG Xinbo | National Key Laboratory of Modern Chinese Medicine Innovation and Manufacturing, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin Modern Innovation Chinese Medicine Technology Co., Ltd., Tianjin 300380, China | songxinbo@tjutcm.edu.cn |
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| Abstract
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| [Objective] To prepare a placebo of Yiqi Qingfei Granules based on machine sensory technology and evaluate its effect. [Methods] Using machine sensory technology and intelligent fitting models，the sensory characteristics of the original drug were systematically analyzed，and placebo imitation of Yiqi Qingfei Granules was carried out. Using objective evaluation methods such as machine vision，electronic tongue，and electronic nose，comprehensively verify the placebo simulation effect. [Results] The color difference ΔE between the placebo and the original drug was 2.236 1，and the color similarity COS value was 0.999 9. The similarity between electronic tongue and electronic nose was 0.931 6 and 0.999 3，respectively. This indicates that the two have highly consistent visual，gustatory，olfactory，and comprehensive sensory characteristics，providing material basis and methodological support for the double-blind clinical trial of Yiqi Qingfei Granules. [Conclusion] This study has broken through the technical bottleneck of sensory attribute simulation for traditional Chinese medicine placebos，providing new ideas for the preparation methods and quality control of similar formulations，and has practical significance for promoting the construction of a standardized evaluation system for traditional Chinese medicine placebos. |
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