| 摘要: |
| [目的] 探究半夏泻心汤加味联合有氧运动治疗儿童单纯性肥胖的疗效。[方法] 选取 96 例单纯性肥胖患儿随机分为对照组和联合组各 48 例。对照组给予有氧运动，联合组加服半夏泻心汤加味。治疗前后比较两组糖脂代谢、血清 25-羟基维生素 D3[25-（OH）D3]、身体质量指数（BMI）、中医证候积分、氧化应激水平，比较两组临床疗效及不良反应发生情况。[结果] 治疗后，联合组总有效率高于对照组（P<0.05）。两组空腹血糖（FPG）、三酰甘油（TG）、总胆固醇（TC）、体质量、BMI、中医证候积分中体倦乏力、形体肥胖、脘腹胀满、丙二醛（MDA）降低，联合组低于对照组（P<0.05）。两组 25-（OH）D3、超氧化物歧化酶（SOD）升高，联合组高于对照组（P<0.05）。联合组中医证候积分中体倦乏力、形体肥胖、脘腹胀满症状消失率均优于对照组（P<0.05）。两组总不良反应经比较无明显差异（P>0.05）。[结论] 半夏泻心汤加味联合有氧运动治疗单纯性肥胖患儿可有效改善糖脂代谢，减轻胰岛素抵抗、减少体内脂质堆积，有助于降低心血管疾病风险，疗效显著。 |
| 关键词: 半夏泻心汤加味 有氧运动 单纯性肥胖 临床疗效 脾虚湿阻证 |
| DOI：10.11656/j.issn.1672-1519.2026.10.05 |
| 分类号:R723.14 |
| 基金项目:2021年常熟市卫生健康委员会科技计划项目（CSWSZD202112）。 |
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| Study on the therapeutic effect of modified Banxia Xiexin Decoction combined with aerobic exercise in the treatment of simple obesity in children with spleen deficiency and dampness obstruction syndrome |
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SHAO Hua, TAO Limei, LU Meihua
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Department of Pediatrics, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu 215500, China
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| Abstract: |
| [Objective] To investigate the therapeutic effect of modified Banxia Xiexin Decoction combined with aerobic exercise in treating simple obesity in children. [Methods] Totally 96 children with simple obesity were randomly assigned into the control group and the combined group，with 48 cases per group. Then the control group adopted aerobic exercise，and the combined group additionally adopted modified Banxia Xiexin Decoction. The glucose and lipid metabolisms，serum 25-hydroxyvitamin D3 [25-（OH）D3]， body mass index（BMI），Chinese medicine syndrome score，and oxidative stress status were compared between the two groups before and after treatment，and the clinical therapeutic effect and occurrence of adverse reactions of the two groups were also compared. [Results] The combined group had a higher overall effective rate than the control group（P<0.05）. The fasting plasma glucose（FPG）， triglycerides（TG），total cholesterol（TC），body weight，BMI，and Chinese medicine syndrome scores（including physical fatigue， obesity，abdominal distension），and malondialdehyde（MDA）in both groups decreased after treatment，with combined group showing lower results than control group（P<0.05）. The 25-（OH）D3 and superoxide dismutase（SOD）increased in both groups after treatment， and combined group had higher results than control group（P<0.05）. The disappearance rate of fatigue，obesity and abdominal distension in the traditional Chinese medicine syndrome score of the combined group was better than that of the control group（P< 0.05）. There was no significant difference in the total adverse reactions between the two groups（P>0.05）. [Conclusion] The modified Banxia Xiexin Decoction combined with aerobic exercise can effectively improve glucose and lipid metabolisms，reduce insulin resistance，and decrease lipid accumulation in children with simple obesity，which helps to reduce the risk of cardiovascular disease and has remarkable therapeutic effects. |
| Key words: modified Banxia Xiexin Decoction aerobic exercise simple obesity clinical therapeutic effect spleen deficiency and dampness obstruction syndrome |
