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| 中药调控NLRP3炎症小体干预急性胰腺炎的研究进展 |
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雷舒蕾1, 王乾昌2, 李昕2, 涂正伟1,2,3, 艾晨阳1,2,3, 崔云峰1,2,3
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1.天津中医药大学南开临床学院, 天津 300100;2.天津医科大学附属南开医院肝胆胰外科, 天津 300100;3.天津大学医学院中西医结合医学中心, 天津 300100
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| 摘要: |
| 急性胰腺炎（AP）起病急，病情进展快，重症患者常伴随全身炎症反应、肠黏膜屏障损伤和肺等远隔器官损伤，寻找有效的炎症调控策略具有重要意义。NOD 样受体热蛋白结构域相关蛋白 3（NLRP3）炎症小体是 AP 炎症反应持续加重的重要调控环节。中药活性成分及复方具有多成分、多靶点的作用特点，近年来在 AP 炎症干预研究中受到关注。文章论述蒽醌类、黄酮类、酚酸类及其他多酚类等中药活性成分，以及清胰汤、大承气汤、柴芩承气汤等复方调控 NLRP3 炎症小体活化的作用机制，并总结其在减轻胰腺损伤、改善肠屏障功能和缓解 AP 相关肺损伤方面的作用特点。现有研究仍以基础实验和临床前研究为主，临床研究证据相对有限。总体来看，中药调控 NLRP3炎症小体干预 AP 具有一定研究价值和应用前景，但相关结论仍需更多高质量临床研究进一步验证。 |
| 关键词: 急性胰腺炎 NLRP3炎症小体 中药活性成分 中药复方 研究进展 |
| DOI：10.11656/j.issn.1672-1519.2026.10.14 |
| 分类号:R657.51 |
| 基金项目:天津市医学重点学科建设项目（TJYXZDXK-3-028C）；天津市教委科研计划重点项目（2024ZD043）；天津市公共卫生科技重大专项重点项目（24ZXGZSY00140）；天津市细胞生态海河实验室“揭榜挂帅”项目（HH24KYZX0014）；河北省中医药管理局中医药类科学研究计划重点项目（T2025036）；天津市南开医院中西医结合防治关键技术及方案优化2022年度重点专项（NKYY-IIT-2022-009-2）；天津市131创新型人才团队（201938）；2024年度天津医科大学护理学科提升计划（2024XKHL29）。 |
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| Research progress on traditional Chinese medicine-mediated regulation of the NLRP3 inflammasome in acute pancreatitis |
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LEI Shulei1, WANG Qianchang2, LI Xin2, TU Zhengwei1,2,3, AI Chenyang1,2,3, CUI Yunfeng1,2,3
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1.Nankai Clinical School of Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300100, China;2.Department of Hepatobiliary and Pancreatic Surgery, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 300100, China;3.ITCWM Medical Center, Faculty of Medicine, Tianjin University, Tianjin 300100, China
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| Abstract: |
| Acute pancreatitis（AP）is characterized by acute onset and rapid progression. Severe AP is often accompanied by a systemic inflammatory response，intestinal mucosal barrier dysfunction，and distant organ injury，particularly lung injury. Therefore，identifying effective strategies for inflammatory regulation is of great significance. The NOD-like receptor family pyrin domain-containing 3 （NLRP3）inflammasome is a key regulatory component involved in the persistent amplification of inflammatory responses in AP. Active components and compound formulas of traditional Chinese medicine（TCM），which are characterized by multi-component and multi-target actions，have attracted increasing attention in recent years for their potential in modulating inflammation in AP. This review discusses the mechanisms by which TCM active components，including anthraquinones，flavonoids，phenolic acids，and other polyphenols，as well as TCM formulas such as Qingyi Decoction，Dachengqi Decoction，and Chaiqin Chengqi Decoction，regulate NLRP3 inflammasome activation. In addition，this review summarizes their effects in alleviating pancreatic injury，improving intestinal barrier function，and mitigating AP-associated lung injury. Current evidence is still mainly derived from basic experimental and preclinical studies，and clinical evidence remains relatively limited. Overall，TCM-mediated regulation of the NLRP3 inflammasome has research value and potential application prospects for AP intervention，but the relevant conclusions still require further validation in high-quality clinical studies. |
| Key words: acute pancreatitis NLRP3 inflammasome active components of traditional Chinese medicine traditional Chinese medicine formulas research progress |
