| 摘要: |
| 炎症性肠病（IBD）发病率逐年上升，其发生与自主神经功能失衡密切相关。针刺可通过调节自主神经功能治疗IBD：电针足三里抑制交感神经-感觉耦合、升高去甲肾上腺素水平以减轻炎症，同时激活迷走神经及其胆碱能抗炎通路，抑制炎症因子分泌并修复肠道屏障。此外，针刺还能调节免疫细胞平衡，促进黏膜修复。针刺为 IBD 治疗提供了多靶点、双向调节的新思路。 |
| 关键词: 炎症性肠病 针刺治疗 自主神经 免疫调节 |
| DOI：10.11656/j.issn.1673-9043.2026.08.14 |
| 分类号:R245;R574.62 |
| 基金项目:国家自然科学基金青年基金项目（8220153296）；国家重点研发计划课题项目（2022YFC3500404）；天津市科技计划项目（22JCZXJC00070）。 |
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| Research progress on the autonomic neuromodulation mechanisms of acupuncture in treating inflammatory bowel disease |
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LI Xue, ZHAO Yining, LI Feiyang, YANG Yuanzhen, WANG Jiaqi, GONG Yinan, XU Zhifang
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School of Acupuncture-Moxibustion and Tuina, Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
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| Abstract: |
| The incidence of inflammatory bowel disease(IBD) has been rising annually，closely linked to autonomic nervous system dysfunction. In traditional Chinese medicine，IBD falls into categories such as“dysentery”and “diarrhea”，with its pathogenesis rooted in spleen deficiency and damp heat accumulation in the intestine. Acupuncture treats IBD by regulating autonomic function. Electroacupuncture at Zusanli（ST36） inhibits sympathetic sensory coupling and elevates norepinephrine levels to reduce inflammation. Simultaneously，it activates the vagus nerve and its cholinergic anti inflammatory pathway，suppressing inflammatory cytokine secretion and repairing the intestinal barrier. Acupoint selection is primarily based on the Stomach Meridian of FootYangming，combined with local and distal points，embodying the holistic regulatory concept of TCM. Additionally， acupuncture modulates immune cell balance（such as the Th17/Treg ratio）and promotes mucosal repair，exerting multi-target，bidirectional regulatory effects. This review systematically summarizes the autonomic mechanisms of acupuncture in IBD treatment，providing scientific evidence for its clinical application. |
| Key words: inflammatory bowel disease acupuncture autonomic nervous system immune regulation |
