| 摘要: |
| 姜黄素、黄芩苷等中药活性成分具有多靶点的抗氧化、抗炎、抗抑郁、抗癌等优势，然其化学稳定性差、水溶性低等缺点严重制约了临床应用。环境响应型水凝胶作为一类智能高分子材料，能够动态响应温度、pH、氧化还原、酶、光、电等微环境信号，实现药物的精准控释与靶向递送。本文系统综述了环境响应型水凝胶的构建机制与功能特性，重点探讨了环境响应型水凝胶系统在中药有效成分递送中的应用，为突破传统中药制剂局限性提供了创新性解决方案。 |
| 关键词: 中药有效成分 环境响应型水凝胶 刺激响应 |
| DOI：10.11656/j.issn.1673-9043.2026.08.15 |
| 分类号:R248;R285.5 |
| 基金项目:天津市教育委员会重点项目（2022ZD041）。 |
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| Application of environment-responsive hydrogel systems in targeted delivery of active ingredients of traditional Chinese medicine |
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YIN Mengyuan, XU Yingyi, ZHANG Qiang, WEI Hongxin, YU Pengxin, QI Xuejie
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College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin 301617, China
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| Abstract: |
| Active ingredients of traditional Chinese medicine（TCM）such as curcumin and baicalin have the advantages of multi target including anti oxidant，anti inflammatory，anti depressant，and anti cancer effects. However，their clinical application is significantly constrained by inherent limitations like poor chemical stability and low water solubility. Environment responsive hydrogels are kind intelligent polymeric materials，which can dynamically respond to microenvironmental signals such as temperature，pH，redox conditions，enzymes，light，and electricity to achieve precise controlled drug release and targeted delivery. This work systematically reviews the construction mechanisms and functional characteristics of environment responsive hydrogels，and focuses on the application of environment-responsive hydrogel systems in the delivery of TCM active ingredients，which provides solutions to overcome the limitations of TCM formulations. |
| Key words: active ingredients of traditional Chinese medicine environment-responsive hydrogel stimuli-responsive |
