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| 小檗科植物淫羊藿主要化学成分及其药理活性研究进展 |
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许昊全1, 朱峰2,3, 霍宗庆2,3, 张浩2,3, 姚景春2,3,4, 田晓轩1, 刘忠3, 秦国飞2,3,4, 张贵民1,2,3,4
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1.天津中医药大学研究生院, 天津 301617;2.鲁南制药集团股份有限公司, 经方与现代中药融合创新全国重点实验室, 临沂 276006;3.山东新时代药业有限公司, 临沂 276006;4.鲁南贝特制药有限公司, 临沂 276006
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| 摘要: |
| 小檗科植物淫羊藿（Epimedium brevicornum Maxim.）是一味传统的补虚类中药，临床上常用于性功能障碍、骨质疏松、类风湿性关节炎等疾病的治疗，具有极高的研究价值。研究表明淫羊藿中含有丰富的黄酮类、木脂素类、萜类、多糖类等化学成分，主要成分为黄酮类化合物，多数化合物具有显著的药理活性，如抗炎、抗抑郁、抗骨质疏松、抗衰老、抗氧化、抗肿瘤等活性，对生殖系统损伤、心肌梗死等有着显著的治疗效果。主要综述了淫羊藿中147种化学成分及其多靶点药理机制的研究进展，旨在填补现有研究对成分-活性关联分析的不足，为淫羊藿的深入研究与开发提供理论依据。 |
| 关键词: 淫羊藿 化学成分 黄酮类化合物 药理活性 |
| DOI：10.11656/j.issn.1673-9043.2026.08.16 |
| 分类号:R284.2;R285.5 |
| 基金项目:泰山产业领军人才计划项目（tscx202312104）；山东省自然科学基金创新联合发展基金项目（ZR2022LZY021）。 |
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| Research of major chemical components and pharmacological activities of Epimedium brevicornum Maxim. |
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XU Haoquan1, ZHU Feng2,3, HUO Zongqing2,3, ZHANG Hao2,3, YAO Jingchun2,3,4, TIAN Xiaoxuan1, LIU Zhong3, QIN Guofei2,3,4, ZHANG Guimin1,2,3,4
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1.Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2.State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co., Ltd., Linyi 276006, China;3.Shandong New Time Pharmaceutical Co., Ltd., Linyi 276006, China;4.Lunan Better Pharmaceutical Co., Ltd., Linyi 276006, China
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| Abstract: |
| Epimedium brevicornum Maxim.，a plant of the Berberidaceae family，is a traditional Chinese medicinal （TCM）herb for tonifying deficiency，which is clinically used for the treatment of sexual dysfunction，osteoporosis， and rheumatoid arthritis and other diseases，which has extremely high research value. Studies have shown that there are abundant flavonoids，lignans，terpenes，and polysaccharides in E. brevicornum，with flavonoids being the main components. Most of the compounds have significant pharmacological activities，such as anti-inflammatory，antidepressant，anti-osteoporosisl，anti-aging，antioxidant，and anti-tumor，etc. It has a remarkable therapeutic effect on syndromes such as reproductive system damage，and myocardial infarction. Research progress on 147 chemical components and their multi target pharmacological mechanisms of E. brevicornum were mainly discussed in this paper，in order to fill the deficiency in the existing research regarding componentactivity correlation analysis，to provide a theoretical basis for the in-depth research and development of E. brevicornum. |
| Key words: Epimedium brevicornum Maxim. chemical composition flavanoid pharmacological activity |
