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| 中药单体及复方调控脂噬改善高脂血症的研究进展 |
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李梦瑶1, 于澄元1, 朱传林2, 张艳军3,4, 尹清晟1, 庄朋伟3,4
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1.天津中医药大学, 天津 301617;2.山东华洋制药有限公司, 淄博 255185;3.天津中医药大学第一附属医院, 天津 300193;4.国家中医针灸临床医学研究中心, 天津 300193
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| 摘要: |
| 高脂血症是一种以脂质代谢紊乱为特征的常见代谢性疾病，是心血管疾病的重要危险因素。脂噬作为一种选择性自噬形式，通过降解细胞内脂滴，在调控脂质稳态中发挥关键作用。近年来多项研究表明，中药单体及复方可通过多靶点、多通路协同调控脂噬，改善高脂血症。文章系统综述了脂噬的分子机制及其在高脂血症中的作用，重点探讨了腺苷酸活化蛋白激酶（AMPK）/哺乳动物雷帕霉素靶蛋白（mTOR）、转录因子EB（TFEB）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等核心信号通路在脂噬调控中的作用，并总结了黄芪甲苷、京尼平苷、大黄素、金丝桃苷、人参皂苷等中药单体及泽泻汤、化瘀祛痰方、昆丹方、五苓散等复方通过调节脂噬改善高脂血症的研究进展，旨在为中药防治高脂血症及相关代谢性疾病提供新的理论依据与研究思路。 |
| 关键词: 中药 脂噬 高脂血症 脂质代谢 |
| DOI：10.11656/j.issn.1672-1519.2026.09.16 |
| 分类号:R589.2 |
| 基金项目:天津市科学技术局科技创新基地项目（24ZYJDSY00280）。 |
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| Research progress of traditional Chinese medicine monomer and compound regulating lipophagy to improve hyperlipidemia |
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LI Mengyao1, YU Chengyuan1, ZHU Zhuanlin2, ZHANG Yanjun3,4, YIN Qingsheng1, ZHUANG Pengwei3,4
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1.Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;2.Shandong Huayang Pharmaceutical Co., Ltd., Zibo 255185, China;3.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;4.National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China
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| Abstract: |
| Hyperlipidemia is a common metabolic disorder characterized by dysregulated lipid metabolism and serves as a significant risk factor for cardiovascular diseases. Lipophagy，a selective form of autophagy，plays a key role in regulating lipid homeostasis by degrading intracellular lipid droplets. Recent studies have shown that single compounds and compound formulations of traditional Chinese medicine（TCM）can ameliorate hyperlipidemia through coordinated regulation of lipophagy via multiple targets and pathways. This article systematically reviews the molecular mechanisms of lipophagy and its role in hyperlipidemia，with a focus on the involvement of core signaling pathways such as AMPK/mTOR，TFEB，and PI3K/Akt in the regulation of lipophagy. It also summarizes recent progress in research on TCM single compounds，including Astragaloside Ⅳ，Geniposide，Emodin，Hyperin，and Ginsenoside，as well as TCM compound formulations such as Zexie Decoction，Huayu Qutan Formula，Kundan Formula，and Wuling Powder in improving hyperlipidemia by modulating lipophagy. The aim is to provide new theoretical foundations and research directions for the prevention and treatment of hyperlipidemia and related metabolic diseases using TCM. |
| Key words: traditional Chinese medicine lipophagy hyperlipidemia lipid metabolism |
